🩺 By Dr Bhavini Patel & Dr Nick Mulrenan — 5 November 2025
As fireworks lit up the Hertfordshire sky this week, we couldn’t help noticing how perfectly they mirror what happens inside our own bodies — countless bursts of energy keeping everything running. In this post, we explore how iron helps your cells spark that same energy from within, right down to their powerhouses: the mitochondria.
Think of your cells as tiny engines — and mitochondria as the spark plugs that keep them running.
These microscopic structures turn the food you eat into a usable form of energy called ATP (adenosine triphosphate) — the body’s internal “currency” for every movement, thought, and repair process.
When mitochondria don’t work efficiently, your body’s energy supply drops. You may feel tired, foggy, or slow to recover, because energy for thinking, moving, and healing becomes limited.
Iron plays a vital part in keeping these energy factories running smoothly — helping your cells convert nutrients into power and keeping you feeling alert and resilient.


Iron isn’t just about haemoglobin and red blood cells — it’s also a core ingredient in your body’s energy production.
Inside each mitochondrion, iron forms part of the enzymes that drive the electron transport chain — the final step in converting nutrients into ATP, the molecule that powers every cell.
When iron levels are low, these enzymes can’t function efficiently, and your cells struggle to release the energy they need.
💡 Imagine a battery circuit missing a vital connector — the current slows down. That’s what happens when the body runs low on iron.
Recent research (2021–2023) confirms that iron deficiency disrupts this mitochondrial process, leaving you with less energy at the cellular level and more fatigue overall.
Feeling constantly tired, foggy, or weak isn’t just about having a “low blood count.”
Even before anaemia develops, a shortage of iron can slow down how your muscles and brain produce energy.
A 2022 review found that low iron levels reduce muscle performance and mental focus, as both tissues have high energy demands.
Restoring iron — through diet, supplements, or IV iron therapy — helps recharge these systems when deficiency is the cause.
💬 At The Iron Infusion Centre, many of our patients notice clearer thinking and better stamina within weeks of correcting low iron levels.


Bonfire Night might be all about warmth and glowing embers — but your body creates its own heat too, through a process called thermogenesis.
Iron plays a key role in this internal heating system.
In 2022, scientists discovered that brown fat — a special type of fat that burns energy to produce heat — relies on iron to function properly.
When iron is low, these cells struggle to generate warmth, leading to slower metabolism and difficulty maintaining body temperature.
So if you often feel the cold more than others, it might not just be the weather — iron could be part of the reason.
It’s not just your cells that rely on iron to create power.
Scientists are using the same chemistry found in our bodies to design new renewable energy systems — developing iron-based batteries and iron–hydrogen technologies as sustainable storage solutions.
A 2024 study from the Royal Society of Chemistry highlighted iron’s unique ability to switch between its chemical forms (Fe²⁺ ↔ Fe³⁺).
This property allows it to store and release energy efficiently — the very same reaction that keeps our mitochondria running every second.
So whether inside the body or powering the next generation of clean energy, iron remains nature’s ultimate charge carrier.


Iron plays several crucial roles in keeping your body energised — not just through red blood cells, but deep within your cells themselves. It powers the mitochondria, the tiny “engines” that generate energy at a cellular level, helping you stay active and alert.
It also supports your brain and muscles — two of the body’s hungriest energy users — allowing you to think clearly, move efficiently, and recover faster.
By aiding heat regulation, iron helps your body produce warmth through thermogenesis — burning calories and maintaining comfort as the colder months set in.
And beyond the body, iron’s unique chemistry is inspiring new frontiers in technology — forming the foundation for next-generation sustainable batteries and clean-energy systems.
References:
Molecular Mechanisms of Iron and Heme Metabolism (Annu Rev Nutr, 2022)
Mitoferrin and Mitochondrial Iron Homeostasis (Cells, 2022)
Assembly and Fate of Mitochondrial Iron–Sulfur Clusters (J Exp Bot, 2023)
Mitochondrial Iron Metabolism: The Crucial Actors in Disease (Review, 2023)
Iron Metabolism and Ferroptosis in Health and Disease (Review, 2025)
Cold hands & feet – Feeling unusually cold, especially in the extremities
Restless legs – An uncomfortable urge to move the legs, often worse at night
Frequent infections – Low iron can weaken the body’s ability to fight illness
Unusual cravings – Some people develop cravings for non-food items (a condition known as pica)
Hair thinning or loss – Shedding more than usual, or noticing patchy thinning
Brittle nails – Nails that split, chip, or break easily
Pale or dull skin – A washed-out or tired appearance due to lower haemoglobin
Dry skin – Skin may feel rough or less vibrant when iron levels are low
Tiredness & fatigue – Feeling drained, even after rest or sleep
Shortness of breath – Struggling with physical activity due to reduced oxygen levels
Poor exercise tolerance – Finding it harder to keep up with usual routines or workouts
Palpitations – Awareness of a racing or irregular heartbeat when iron is low
Brain fog & poor focus - Trouble focusing, forgetfulness, or feeling mentally sluggish
Headaches – Low oxygen delivery can lead to frequent or unexplained headaches
Dizziness & light-headedness – A common result of reduced oxygen in the blood
Low mood & irritability – Iron deficiency can affect emotional balance and resilience